Typical application cases of centrifuges in the biopharmaceutical field
Category: Application Cases
Release Time: 2025-07-17
As a critical piece of equipment that leverages centrifugal force to achieve material separation, centrifuges are widely used across various fields—such as biomedicine, food processing, and environmental monitoring—thanks to their efficient and precise separation capabilities. Heng'er Biotech specializes in the research and development of tabletop centrifuges, offering high-speed and low-speed product lines that stand out for their compact footprint, user-friendly operation, and reliable separation performance. These models have become the preferred choice for laboratories and small-to-medium-sized production lines in diverse industries. Below, we’ll explore the application principles, equipment selection criteria, and tangible outcomes of Heng'er Biotech’s tabletop centrifuges through real-world cases in the biomedical sector, highlighting their core value in specialized scenarios.
Biopharmaceutical Field: Blood Component Separation and Plasma Sample Preparation
In clinical testing and biopharmaceutical research and development, the precise separation of blood components is a critical step, requiring efficient isolation while preserving the activity of each component. A certain biolaboratory needs to separate plasma and red blood cell samples from collected whole blood for use in immunological assays. However, conventional centrifugal equipment suffers from unstable rotation speeds and inadequate temperature control accuracy, which can easily lead to sample inactivation and compromise the reliability of test results.
(1) Application Requirements and Challenges
Whole blood consists of plasma (density 1.025–1.030 g/cm³), red blood cells (density 1.080–1.090 g/cm³), white blood cells, and other components. Each day, the laboratory needs to process 50–80 whole blood samples, with each sample measuring 10–20 mL. The core requirements are: after separation, plasma purity must reach at least 99%, and red blood cell recovery rate must exceed 95%. Additionally, during the separation process, sample temperature must be maintained steadily between 4–6°C to prevent protein denaturation. At the same time, the equipment should fit comfortably within the lab’s limited space, and the operational workflow must be simple enough for healthcare staff to quickly become proficient.
(2) Centrifuge Selection and Application Principles
Choose the Heng'er Bio desktop low-speed centrifuge (Model: PRO1406), a device specifically designed for biological sample separation. It features a speed range of 6,000 rpm and can accommodate up to four 145 mL centrifuge tubes. With compact dimensions of just 490 × 394 × 370 mm, it can be conveniently placed directly on a laboratory workbench, saving valuable bench space. Its key advantages lie in its precise speed control and advanced temperature management system, ensuring gentle separation of blood components while maintaining optimal conditions.
When working, place the anticoagulated whole blood sample into a centrifuge tube and symmetrically position it within the rotor of the device. Set the speed to 3500 rpm, the centrifugation time to 15 minutes, and the temperature at 5°C. Once the equipment starts, the variable-frequency motor drives the rotor to spin at high speed, generating a centrifugal force equivalent to approximately 1800 times Earth's gravity. As a result, the denser red blood cells settle toward the bottom of the centrifuge tube, forming a distinct red cell layer, while the less dense plasma floats on top. The thin middle layer contains white blood cells and platelets. After centrifugation is complete, carefully pipette and collect the upper-layer plasma using a micropipette, yielding a highly pure plasma sample. The sedimented red blood cells at the bottom can then be used for subsequent cell experiments. Additionally, the device is equipped with a safety door lock and an over-speed alarm system, preventing sample leakage or equipment malfunction during operation and ensuring experimental safety.
(3) Application Outcomes
After introducing the Heng'er Biotech desktop low-speed centrifuge, the laboratory saw a significant improvement in blood sample separation efficiency. The device can process 24 samples per batch, increasing the daily throughput from the original 50 to 80 samples—fully meeting the demands of testing requirements. Moreover, the purity of the separated plasma reached 99.2%, while the red blood cell recovery rate was 96%. Importantly, the sample activity remained fully compliant with testing standards, resulting in a 15% increase in the accuracy of test data. Additionally, the equipment features a user-friendly touch-screen interface, enabling operators to perform tasks independently after just one hour of training, thereby minimizing human error. Its compact, desktop design also eliminates the need for dedicated floor space, allowing seamless integration with other lab equipment and providing greater flexibility in optimizing the overall experimental workspace layout.
Category: Typical application cases of centrifuges in the biopharmaceutical field